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CVT Series

CVT inspection machines have been devised to process highly valuable drugs to the highest inspection speed, reaching up to 48,000 units per hour
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CVT Series

CVT inspection machines have been devised to process highly valuable drugs to the highest inspection speed, reaching up to 48,000 units per hour
GET A QUOTATION

Unique technology, unique performance

InnoScan inspection machines are equipped with a unique technolgy to achieve a market-leading performance in terms of high detection rate, while maintaining a low false rejection rate.

To obtain superior inspection performances at high-speed, InnoScan uses Line Scan Camera, Matrix Camera and High-Voltage leak Detection. The application of the three complementing main technologies gives the InnoScan inspection machines the flexibility to detect particulate matters, closure integrity issues and cosmetic defects in cartridges, vials, ampoules, syringes and special primary packaging material.

Take the tour below to understand how InnoScan applies different technologies for automated inspection.


 

Defect Types

In general, all defects on finished parenteral products can be categorized into three major groups:

  • Particulate matter
  • Closure integrity issues
  • Cosmetic defects

Particulate Matter

A particulate matter is defined as a fragment/particle external to the formulation and filling process.

A particulate matter is typically considered as a critical defect due to the impact when injected into the body. Moreover, particulate matter could potentially host harmful microorganisms causing contamination of the product.

Typical materials of a particulate matter are fiber, glass, rubber/plastic and metal.

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Closure Integrity Issues

A closure integrity issue is defined as a breach of the sterile environment of the closed primary packaging material.

A closure integrity issue is typically considered as a critical defect due to the potential contamination of the product.

Typically, closure integrity breaches appear on the glass barrel, plunger area and stopper area.

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Cosmetic Defects

Cosmetic defects do not typically alter the product quality or the product efficacy. However, some cosmetic defects can potentially develop to a critical defect, e.g. from a deep scratch to a penetrating crack compromising the product sterility.

Common cosmetic defects are scratches, dirt or dust on the glass barrel and scratches or dents on the cap.

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Inspection Technology

To cover the full range of inspection, particulate matters, closure integrity issues and cosmetic defects, InnoScan applies three main technologies:

  • Matrix Camera
  • Line Scan Camera
  • High-Voltage Leak Detection

Applying these complementing technologies facilitates the market-leading performance InnoScan machines are known for.

Matrix Scan

Shape or pattern recognition

A Matrix Camera is a commonly used imaging technology in the industry, yet best known for the recreational application. The camera sensors are organized in a matrix (grid), hence the matrix camera composes images of objects in a similar manner as the human eye perceives.

For inspection, InnoScan applies a Matrix Camera when shape or pattern recognition is required, e.g. inspection of cosmetic defects.

Line Scan

For precision imaging purposes

The Line Scan Camera is a high-resolution imaging technology used for precision imaging purposes.

In contrast to the Matrix Camera, the Line Scan Camera sensors are organized in one single column enabling the camera to acquire several thousand lines per second.

The image of a Line Scan is constructed by stitching the acquired lines together. The Line Scan Camera is suitable for imaging moving objects and 'unwrapping' three dimensional surfaces into two dimensional images.

For inspection, InnoScan uses Line Scan Cameras for high-resolution imaging of defects to the size of 50 μm, e.g. inspection of particulate matters.

HVLD

For detecting leaking cracks

High-Voltage Leak Detection (HVLD) is a robust method for detecting leaking cracks in the primary packaging material. The technology builds on the principle that glass is an isolator of the current, while the liquid/product is a conductor.

The Principle

The high-voltage is applied by dedicated electrodes on a predefined area. In the unbroken glass the current traverses along the glass wall hence, the measured current at the reference electrode is small due to the intrinsic resistance in the glass.

Leaking Crack

In case of a closure integrity breach, e.g. a crack in the glass, the system transforms to a short-circuit where the current traverses along the path of least resistance.  In this case, the current measured at the reference electrode is larger compared to a undamaged container.

 


 

CVT Cartridges

CVT inspection machine for cartridges has been devised to process highly valuable drugs to an unparalleled speed: in fact, it features the highest inspection speed available today, reaching up to 48,000 units per hour, inspecting for particulates, closure integrity and cosmetic defects from water-like products to the densest suspensions or emulsions.

The InnoScan inspection machine for cartridges ensures the greatest efficiency in the market: >95% detection rate and <0.5% false reject at the same time for liquid product.

InnoScan is a world leader in the inspection field with unmatched capacity thanks to its patented imaging technology dedicated to the inspection of difficult products like foaming liquid, suspension and viscous/gel-like products.

  • Sustained inspection capacity up to 48,000/h
  • Pre-inspection to maintain high uptime
  • Short format change-over time including format dependent index positions
  • Flexible configuration to up- and downstream processes
  • Carousel with 100 individual rotation units to ensure proper re-homogenization of suspension Capacity: particulates, closure integrity and cosmetic defects
  • Integrated full body HVLD, without increasing footprint
  • Automated light regulation for consistent inspection
  • Gentle line handling with a minimal number of transmissions
  • 100% reconciliation for quality assurance
  • Automated re-circulation of ejected cartridges
  • Freely configurable outlets for maximum production flexibility
  • The single inspection system at maximum speed includes a no triple-fourfold vision system to validate and keep equalized in production
  • Particulate Matter
  • Closure Integrity
  • Cosmetic Defects
  • Includes a large carousel for correct preparation at max speed even of thick suspensions
  • Can accommodate a pre-spinning carousel with ­ intermediate buffer to efficiently handle bubble-prone products
  • Features a flexible input with no glass to glass contact even for unstable products
  • Features a flexible output for unstable products with integrated robotic palletizer

 

CVT Syringes

InnoScan inspection machine for syringes provides the highest inspection speed available today, reaching up to 36,900 units per hour.

It is suitable to inspect for particulates at product top, bottom, side, hidden particles, closure integrity and cosmetic defects in water-like products to the densest suspensions or emulsions thanks to an advanced particle inspection technology for detection of difficult matters i.e. glass flakes.

Moreover CVT Syringe is also able to detect of chips and cracks despite product dust on walls.

CVT Syringe ensures the greatest efficiency in the market: typically >95% detection rate and <5% false reject and offers unmatched capacity thanks to its patented imaging technology dedicated to inspecting difficult products like foaming liquid, suspension and viscous/gel-like products

  • Sustained inspection capacity up to 39,600/h
  • Short format change-over time including format dependent index positions
  • Flexible integration to non-glass contact line handling systems including integration of batch data from line handling systems
  • Carousel with 100 individual rotation units to ensure proper re-homogenization of suspensions
  • Capacity: particulates, closure integrity and cosmetic defects
  • Integrated full body HVLD, without increasing footprint
  • Pre-inspection of needle cap and flange to maintain high uptime
  • Integrated head space analysis, without increasing footprint
  • Automated light regulation for consistent inspection
  • Gentle line handling with a minimal number of transmissions
  • 100% reconciliation for quality assurance
  • Automated re-circulation of ejected syringes
  • Freely configurable outlets for maximum production flexibility
  • The single inspection system at maximum speed includes a no triple-fourfold vision system to validate and keep equalized in production
  • Freely configurable outlets
  • Particulate Matter
  • Closure Integrity
  • Cosmetic Defects
  • Includes a large carousel for correct preparation at max speed even of thick suspensions
  • Can accommodate a pre-spinning carousel with intermediate buffer to efficiently handle bubble-prone products
  • Extremely compact and integrated de-nesting and re-nesting unit with no glass to glass contact

 

CVT Vials

CVT inspection machine for vials set new standards in terms of inspection speed and inspection quality reaching up to 39,600 units per hours for liquid-filled vials.

InnoScan CVT vials feature a unique technology suitable for liquid and lyophilized drug inspection.

CVT Vials is, in fact, the best solution in the market to inspect for particulates, closure integrity and cosmetic defects from water-like products to the most dense suspensions or emulsions, even in case of product dust on walls.

CVT technology allows the body inspection of chips and cracks and of particulate matter at product top, bottom, side, including hidden particles.

It ensures the greatest efficiency in the market: typically >95% detection rate and <5% false reject offering unmatched capacity thanks to its patented imaging technology dedicated to inspect difficult products like foaming liquid, suspension and viscous/gel-like products.

  • Sustained inspection capacity up to 39,600/h for liquid drugs
  • Sustained inspection capacity up to 18,000/h for lyophilized drugs
  • Integrated full body HVLD, including inversion module for low fill containers
  • Freely configurable outlets
  • Carousel with 100 individual rotation units to ensure proper re-homogenization of suspensions
  • Capacity: particulates, closure integrity and cosmetic defects
  • Integrated head space analysis, without increasing footprint
  • Automated light regulation for consistent inspection
  • Gentle line handling with a minimal number of transmissions
  • 100% reconciliation for quality assurance
  • Automated re-circulation of ejected vials
  • Freely configurable outlets for maximum production flexibility
  • The single inspection system at maximum speed includes a no triple-fourfold vision system to validate and keep equalized in production
  • Particulate Matter
  • Closure Integrity
  • Cosmetic Defects
  • Includes a large carousel for correct preparation at max speed even of thick suspensions: thanks to its 100 positions carousel, it can perform combined inspection of both liquid and lyophilized products
  • It can accommodate a pre-spinning carousel with ­intermediate buffer to efficiently handle bubble-prone products
  • Features a flexible input with no glass to glass contact
  • Features a flexible output for unstable products with integrated robotic palletizer

 

Our Services
All of InnoScan's work is done in accordance with Innoscan's Quality System ...
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